2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Opioid Receptor

Opioid Receptor

Opioid Receptor

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Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.

Opioid Receptor Isoform Specific Products:

Opioid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156992
    AT-035
    		Agonist
    AT-035 is a high affinity and selective NOP agonist.
    AT-035
  • HY-168816
    Dipyanone hydrochloride
    Dipyanone hydrochloride is structurally similar to known opioids.
    Dipyanone hydrochloride
  • HY-123689R
    Samidorphan (Standard)
    		Antagonist
    Samidorphan (Standard) is the analytical standard of Samidorphan. This product is intended for research and analytical applications. Samidorphan (ALKS-33) is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo. Samidorphan can improve the behavior of depressed animals.
    Samidorphan (Standard)
  • HY-123689R
    Samidorphan (Standard)
    		Modulator
    Samidorphan (Standard) is the analytical standard of Samidorphan. This product is intended for research and analytical applications. Samidorphan (ALKS-33) is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo. Samidorphan can improve the behavior of depressed animals.
    Samidorphan (Standard)
  • HY-130367
    U-48520
    		Agonist
    U-48520 is an agonist for μ-opioid receptor with EC50 of 1561 nM.
    U-48520
  • HY-13274A
    JTC-801 free base
    		Antagonist
    JTC-801 free base is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a Ki value of 8.2?nM.
    JTC-801 free base
  • HY-119914
    Bromadol
    Bromadol is an opioid.
    Bromadol
  • HY-137920
    Salvinorin A propionate
    		Agonist
    Salvinorin A (Divinorin A) propionate is a potent, unique and short-acting high efficacy kappa-opioid receptor (KOPr) agonist with Ki value of 4.3 nm. Salvinorin A propionate is a non-nitrogenous neoclerodane isolated from Salvia divinorum.
    Salvinorin A propionate
  • HY-114452R
    LY2940094 (Standard)
    		Antagonist
    LY2940094 (Standard) is the analytical standard of LY2940094. This product is intended for research and analytical applications. LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models.
    LY2940094 (Standard)
  • HY-W714505
    AH 7563
    		Ligand
    AH 7563 structurally belongs to the opioid compounds and exhibits analgesic activity. In the phenylquinone test and hot plate test, the ED50 of AH 7563 for analgesia in mice were 15.3 mg/kg (orally) and 15.5 mg/kg (subcutaneous injection), respectively.
    AH 7563
  • HY-104006R
    CYM51010 (Standard)
    		Agonist
    CYM51010 (Standard) is the analytical standard of CYM51010 (HY-104006). This product is intended for research and analytical applications. CYM51010 is a biased ligand of μ-opioid receptor – δ-opioid receptor heterodimers with an EC50 of 403 nM. CYM51010 exhibits anti-nociceptive activity similar to morphine but with a decreased levels of tolerance development and withdrawal symptoms.
    CYM51010 (Standard)
  • HY-168818
    N-(1-Phenethyl-4-piperidyl)-N-phenethylpropanamide hydrochloride
    N-(1-Phenethyl-4-piperidyl)-N-phenethylpropanamide hydrochloride is structurally similar to known opioids.
    N-(1-Phenethyl-4-piperidyl)-N-phenethylpropanamide hydrochloride
  • HY-118987
    AT-127
    		Agonist
    AT-127 is a NOP receptor partial agonist, stimulating NOP/G-protein interaction in a concentration dependent manner.
    AT-127
  • HY-158899
    3,4-Ethylenedioxy U-51754 hydrochloride
    3,4-Ethylenedioxy U-51754 hydrochloride is structurally similar to known opioids.
    3,4-Ethylenedioxy U-51754 hydrochloride
  • HY-169822
    5′-Guanidinonaltrindole
    		Antagonist
    5′-Guanidinonaltrindole (GNTI) is a selective kappa opioid receptor antagonist.
    5′-Guanidinonaltrindole
  • HY-107722R
    SCH 221510 (Standard)
    		Agonist
    SCH 221510 (Standard) is the analytical standard of SCH 221510 (HY-107722). This product is intended for research and analytical applications. SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC50 of 12 nM and Ki of 0.3 nM. SCH 221510 shows an anxiolytic-like effect.
    SCH 221510 (Standard)
  • HY-105389
    Tramadol N-oxide
    		Agonist
    Tramadol N-oxide (RWJ 38705) is an analgesic. Tramadol N-oxide sproduces dose-related, long-lasting antinociception. Tramadol N-oxide has affinity for μ opioid receptor (Ki = 38.5 μM) and δ, κ receptors (Ki > 100 μM). Tramadol N-oxide can be used for the study of analgesic effect.
    Tramadol N-oxide
  • HY-158967
    3,4-Difluoro-N-desmethyl U-47700 hydrochloride
    3,4-Difluoro-N-desmethyl U-47700 hydrochloride is a utopioid.
    3,4-Difluoro-N-desmethyl U-47700 hydrochloride
  • HY-W725198
    3,4-Difluoro U-49900 hydrochloride
    3,4-Difluoro U-49900 hydrochloride is an opioid.
    3,4-Difluoro U-49900 hydrochloride
  • HY-W683876
    Desmethylmoramide
    Desmethylmoramide is structurally similar to known opioids. Desmethylmoramide has analgesic activity in rodents.
    Desmethylmoramide
Cat. No. Product Name / Synonyms Application Reactivity
Opioid Receptor Isoform Comparison

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